Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging.

Shota YanagiTomoya SugaiTakuma NoguchiMasato KawakamiMakoto SasakiShinsuke NiwaAsako SugimotoHaruhiko Fuwa

Published in: Organic & biomolecular chemistry (2020)

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

Keyphrases

endoplasmic reticulum
high resolution
quantum dots
living cells
structure activity relationship
single molecule
computed tomography
pet imaging
pet ct