SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex.

Chunling MaFang WangBing HanXiaoli ZhongFusheng SiJian YeEddy C HsuehLynn RobbinsSusan M KieferYanping ZhangPamela HunborgMark A VarvaresMichael RauchmanGuangyong Peng

Published in: Molecular cancer (2018)

Our studies indicate that the developmental control gene SALL1 plays a critical role in tumor suppression by recruiting the NuRD complex and thereby inducing cell senescence in breast cancer cells.

Keyphrases

breast cancer cells
dna damage
endothelial cells
single cell
stress induced
cell therapy
genome wide
copy number
gene expression
genome wide identification
transcription factor