Mesenchymal stem cell-derived exosomes improve neurogenesis and cognitive function of mice with methamphetamine addiction: A novel treatment approach.
Solmaz FallahiHamid Soltani ZangbarFereshteh FarajdokhtReza RahbarghaziRafighe GhiasiGisou MohaddesPublished in: CNS neuroscience & therapeutics (2024)
Our findings indicate that BMSC-exosomes mitigated METH-caused cognitive dysfunction by improving neurogenesis and inhibiting neuroinflammation in the hippocampus.
Keyphrases
- mesenchymal stem cells
- cerebral ischemia
- umbilical cord
- stem cells
- bone marrow
- cognitive impairment
- signaling pathway
- neural stem cells
- traumatic brain injury
- blood brain barrier
- cell therapy
- type diabetes
- lipopolysaccharide induced
- high fat diet induced
- lps induced
- combination therapy
- adipose tissue
- metabolic syndrome
- replacement therapy