Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study.
Adam CorkenJerry WareJunqiang DaiJohn M ArthurSusan SmythClayton L DavisJuan LiuTerry O HarvilleMilind A PhadnisJawahar Lal MehtaYasir RahmatallahNishank JainPublished in: Kidney360 (2022)
Attenuated interactions between platelets and leukocytes in the CKD state coincided with no change in platelet activation status, an altered differentiation state of monocytes, and heightened inflammatory markers. Platelet-derived cytokines were one of the central cytokines in patients with CKD that were tightly correlated with others. DAPT had multifaceted effects on thromboinflammation, suggesting that there is platelet-dependent and -independent inflammation in stage 4 or 5 CKD.