Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Kelly WunBetty R TheriaultJoseph F PierreEdmund B ChenVanessa A LeoneKatharine G HarrisLiqun XiongQun JiangMelanie SpedaleOwen M EskandariEugene B ChangKaren S HoPublished in: PloS one (2018)
GF mice have attenuated neointimal hyperplasia development compared to CONV-R mice, which is likely related to altered kinetics of wound healing and acute inflammation. Recognizing the role of commensals in the regulation of arterial remodeling will provide a deeper understanding of the pathophysiology of restenosis and support strategies to treat or reduce restenosis risk by manipulating microbiota.
Keyphrases
- liver failure
- oxidative stress
- respiratory failure
- drug induced
- high fat diet induced
- wound healing
- vascular smooth muscle cells
- smooth muscle
- aortic dissection
- hepatitis b virus
- type diabetes
- intensive care unit
- metabolic syndrome
- insulin resistance
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome