Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles.

Laura Le GallWilliam J DuddyCecile MartinatVirginie MariotOwen ConnollyVanessa MillaEkene AnakorZamalou G OuandaogoStephanie MillecampsJeanne LainéUdaya Geetha VijayakumarSusan KnoblachCedric RaoulOlivier LucasJean Philippe LoefflerPeter BedeAnthony BehinHelene BlascoGaelle BruneteauMaria Del Mar AmadorDavid DevosAlexandre HenriquesAdele HestersLucette LacomblezPascal LaforetTimothee LangletPascal LeblancNadine Le ForestierThierry MaisonobeVincent MeiningerLaura RobelinFrancois SalachasTanya StojkovicGiorgia QuerinJulie DumonceauxGillian Butler BrowneJose-Luis González De AguilarStephanie DuguezPierre Francois Pradat

Published in: Journal of cachexia, sarcopenia and muscle (2022)

ALS muscle vesicles are shown to be toxic to MNs, which establishes the skeletal muscle as a potential source of vesicle-mediated toxicity in ALS.

Keyphrases

amyotrophic lateral sclerosis
skeletal muscle
end stage renal disease
ejection fraction
newly diagnosed
insulin resistance
peritoneal dialysis
prognostic factors
type diabetes
climate change
late onset
signaling pathway
cell death
cell proliferation
patient reported