Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.
Mohammadreza Alizadeh-GhodsiKatie L OwenScott L TownleyDamien ZankerSamuel P G RollinAdrienne R HansonRaj Kumar ShresthaJohn ToubiaTessa GargettIgor ChernukhinJennii LuuKarla J CowleyAshlee ClarkJason S CarrollKaylene J SimpsonJean M WinterMitchell G LawrenceLisa M ButlerGail P RisbridgerBenjamin ThierryRenea A TaylorTheresa E HickeyBelinda S ParkerWayne D TilleyLuke A SelthPublished in: Cancer research communications (2022)
Our study demonstrates that potent androgen stimulation of prostate cancer cells can elicit a viral mimicry response, resulting in enhanced IFN signaling. This finding may have implications for the development of strategies to sensitize prostate cancer to immunotherapies.