Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis.
Ming-Horng TsaiMiao-Ching ChiJen-Fu HsuI-Ta LeeKo-Ming LinMei-Ling FangMing-Hsueh LeeChiang-Wen LeeJu-Fang LiuPublished in: Cells (2020)
microRNA-137 plays an important role in PMs-induced RA acute exacerbation through MAPK signaling pathways and IL-6/COX-II activation. Targeting these mechanisms can potentially be used to develop new therapeutic strategies and prevention of RA inflammation in the future.
Keyphrases
- particulate matter
- rheumatoid arthritis
- signaling pathway
- disease activity
- air pollution
- oxidative stress
- drug induced
- pi k akt
- ankylosing spondylitis
- respiratory failure
- chronic obstructive pulmonary disease
- liver failure
- diabetic rats
- interstitial lung disease
- systemic lupus erythematosus
- induced apoptosis
- high glucose
- cell death
- dna damage
- current status
- systemic sclerosis
- aortic dissection
- hepatitis b virus
- extracorporeal membrane oxygenation
- reactive oxygen species
- acute respiratory distress syndrome
- mechanical ventilation