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Review of the Different Outcomes Produced by Genetic Knock Out of the Long Non-coding microRNA-host-gene MIR22HG versus Pharmacologic Antagonism of its Intragenic microRNA product miR-22-3p.

Marc ThibonnierSujoy Ghosh
Published in: MicroRNA (Shariqah, United Arab Emirates) (2024)
From a therapeutic viewpoint, genetic inactivation of a lncMIRHG and pharmaco-logic antagonism of the guide strand of its related intragenic miRNA produce different results. This should be expected as lncMIRHGs play dual roles, both as lncRNA and as a source for primary miRNA transcripts.
Keyphrases
  • genome wide
  • copy number
  • long non coding rna
  • long noncoding rna
  • cell proliferation
  • dna methylation
  • type diabetes
  • adipose tissue
  • glycemic control