Fatal Respiratory Diphtheria Caused by ß-Lactam-Resistant Corynebacterium diphtheriae.

Brian M FordeAndrew HendersonElliott G PlayfordDavid LookeBelinda C HendersonCatherine WatsonJason A SteenHanna E SidjabatGordon LaurieSharmini MuttaiyahGraeme R NimmoGuy LampeHelen SmithAmy V JennisonBrad McCallHeidi CarrollMatthew A CooperDavid L PatersonScott A Beatson

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

We have identified a novel mechanism of inducible antibiotic resistance whereby isolates that appear to be carbapenem susceptible on initial testing can develop in vivo resistance to carbapenems with repeated exposure. This phenomenon could have significant implications for the treatment of C. diphtheriae infection, and may lead to clinical failure.

Keyphrases

gram negative
acinetobacter baumannii
multidrug resistant
combination therapy
replacement therapy