Clinical benefit of methotrexate plus vinorelbine chemotherapy for desmoid fibromatosis (DF) and correlation of treatment response with MRI.

Katrina M IngleySally M BurtenshawNicole C TheobaldsLawrence M WhiteMartin E BlacksteinRebecca A GladdySeng ThipphavongAbha A Gupta

Published in: Cancer medicine (2019)

Low-dose MTX/VNL for a defined duration has high efficacy with sustained benefit and minimal toxicity for treating DF. Vtumor and T2 signal might better predict treatment response than RECIST.

Keyphrases

low dose
high dose
magnetic resonance imaging
contrast enhanced
oxidative stress
locally advanced
phase ii study
clinical trial