Understanding the role of genetic variability in LRRK2 in Indian population.

Asha KishoreAshwin Ashok Kumar SreelathaMarc SturmFelix von-ZweydorfLasse PihlstrømFrancesco RaimondiRob RussellPeter LichtnerMoinak BanerjeeSyam KrishnanRoopa RajanDivya Kalikavil PuthenveeduSun Ju Chungnull nullnull nullPeter BauerOlaf RiessChristian Johannes GloecknerRejko KrugerThomas GasserManu Sharma

Published in: Movement disorders : official journal of the Movement Disorder Society (2018)

Our study, for the first time, identified novel missense variants for LRRK2, specific for the Indian population, and showed that a novel missense variant in the kinase domain modifies kinase activity in vitro. © 2018 International Parkinson and Movement Disorder Society.

Keyphrases

intellectual disability
copy number
protein kinase
tyrosine kinase
genome wide
dna methylation
autism spectrum disorder
gene expression