Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.

Bing ZhuYan LiuSpring HwangKailey ArchuletaHuijie HuangAlex CamposRabi MuradJuan Piña-CrespoHuaxi XuTimothy Y Huang

Published in: Molecular neurodegeneration (2022)

Together, our results reveal a role for Trem2 in suppressing exosomal tau pathogenicity, and demonstrates that Trem2 deletion can enhance tau trafficking, distribution and seeding through microglial exosomes.

Keyphrases

cerebrospinal fluid
mesenchymal stem cells
inflammatory response
stem cells
neuropathic pain
signaling pathway
lipopolysaccharide induced
genome wide
lps induced
escherichia coli
gene expression
staphylococcus aureus
cystic fibrosis
pseudomonas aeruginosa