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Cisplatin-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) with life-threatening hyponatraemia.

Aaron C TanGavin M Marx
Published in: BMJ case reports (2018)
We present a case of cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with metastatic recurrent urothelial carcinoma. Cisplatin-induced SIADH is an uncommon but potentially life-threatening toxicity. Pharmacogenetic characteristics may result in different toxicity profiles in different populations. With such widespread use of cisplatin in a diverse range of cancers, prompt recognition is crucial to detect and prevent severe neurological sequelae.
Keyphrases
  • case report
  • oxidative stress
  • squamous cell carcinoma
  • small cell lung cancer
  • early onset
  • young adults
  • subarachnoid hemorrhage