Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus.

Published in: Epigenetics & chromatin (2017)

We propose that a dynamic interaction switch between PcG proteins and an elongation factor enables stress-inducible genes to efficiently switch between ON/OFF states in the presence/absence of the activating stimulus.

Keyphrases

heat shock
heat stress
heat shock protein
signaling pathway
gene expression
genome wide
transcription factor
genome wide identification
genome wide association study
genome wide analysis