The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS.

Tim RahmelHartmuth NowakKatharina RumpWinfried SiffertJürgen PetersMichael Adamzik

Published in: PloS one (2018)

In pneumonia evoked ARDS, the AA genotype of the AQP5 promoter polymorphism is associated with a decreased recovery rate from AKI and this is independent of fluid balance. Consequently, the role of AQP5 in influencing AKI likely rests in factors other than fluid balance.

Keyphrases

acute kidney injury
acute respiratory distress syndrome
dna methylation
extracorporeal membrane oxygenation
mechanical ventilation
transcription factor
respiratory failure
gene expression
community acquired pneumonia