The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).

Sirwan K L DarweeshQiong YangMary L BiggsJohanna JakobsdottirShuo LiDaniel S EvansJoshua C BisTamara B HarrisRamachandran S VasanNuno R ZilhaoMohsen GhanbariM Arfan IkramLenore LaunerBruce M PsatyGregory J TranahAlexander M KulminskiVilmundur GudnasonSudha Seshadrinull null

Published in: PloS one (2019)

Compared with APOE-ε3, APOE-ε2 is associated with prolonged survival, whereas mortality risk is increased for APOE-ε4 carriers. Further collaborative efforts are needed to unravel the role of APOE and in particular APOE-ε2 in health and disease.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
healthcare
public health
mental health
adipose tissue
risk assessment
health information
climate change