Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.

Mickaël CanouilAmna KhamisElina KeikkalaSandra HummelStephane LobbensAmélie BonnefondFabien DelahayeEvangelia TzalaSanna MustaniemiMarja VääräsmäkiMarjo-Riitta JarvelinSylvain SebertEero KajantiePhillippe FroguelToby Andrew

Published in: Diabetes care (2021)

Our study reveals the potential complexity of the epigenetic transmission between mothers with GDM and their offspring, likely determined by not only GDM exposure but also other factors indicated by maternal epigenetic status, such as maternal metabolic history.

Keyphrases

dna methylation
pregnancy outcomes
gene expression
genome wide
high fat diet
pregnant women
physical activity
adipose tissue
insulin resistance
human health