Dual Key-Activated Nir-I/Ii Fluorescence Probe for Monitoring Photodynamic And Photothermal Synergistic Therapy Efficacy.

As the cancer markers, H 2 O 2 and viscosity play an essential role in the development of tumors. Meanwhile, based on the performance of near-infrared (NIR) fluorescence imaging and the high efficiency of PDT and PTT synergistic therapy, it is urgent to develop a dual-key (H 2 O 2 and viscosity) activated fluorescence probe for cancer phototherapy. Herein, a NIR-I/II fluorescence probe named BX-B is reported. In the presence of both H 2 O 2 and viscosity, the fluorescence signal of NIR-I (810 nm) and NIR-II (945 nm) can be released. In the presence of H 2 O 2 , the PDT and PTT effects are shown. BX-B has been used to monitor its therapeutic effects in cancer cells and tumor-bearing mice due to the increased viscosity caused by PDT and PTT. In addition, the tumors of mice treated with BX-B are almost completely ablated after the laser irradiation based on its PDT and PTT synergistic therapy. This work provides a reliable platform for effective cancer treatment and immediate evaluation of therapeutic effects. This article is protected by copyright. All rights reserved.