Treatment of Trypanosoma cruzi with 2-bromopalmitate alters morphology, endocytosis, differentiation and infectivity.
Cassiano Martin BatistaRafael Luis KesslerIriane EgerMaurilio José SoaresPublished in: BMC cell biology (2018)
Our results indicate that 2-BP inhibits key cellular processes of T. cruzi that may be regulated by palmitoylation of vital proteins and suggest a metacyclic trypomastigote unique target dependency during the parasite development.