mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.
Lun LiAileen A RenSiqi GaoYourong S SuJisheng YangJenna BockmanPatricia Mericko-IshizukaJoanna GriffinRobert ShenkarRoberto J Alcazar-FelixThomas MooreRhonda LightleDorothy DeBiasseIssam A AwadDouglas A MarchukMark L KahnJan-Karl BurkhardtPublished in: Stroke (2023)
Our findings further establish this adult CCM model as a valuable preclinical model and support clinical testing of rapamycin to treat rapidly growing human CCMs.