Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats.
Francesca FrescuraTibor StarkMaria C TomasiniSerena Di MartinoJana Ruda-KucerovaFilippo DragoLuca FerraroVincenzo MicaleSarah BeggiatoPublished in: Pharmacological reports : PR (2024)
The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.