Differences in Leukocyte Transcriptomes of Morbidly Obese Patients With High Output Heart Failure: A Pilot Study.

Samantha A Cintron Janet D Pierce Mihaela E Sardiu Diane E Mahoney Jill N Peltzer Bhanu Gupta Qiuhua Shen

Published in: International journal of heart failure (2023)

We are the first to report the differential gene expression in patients with obesity-related HOHF and reveal the various pathophysiologic mechanisms underlying the disease. Further research is needed to determine the role of cellular function and maintenance, inflammation, and iron homeostasis in obesity-related HOHF.

Keyphrases

weight loss
metabolic syndrome
gene expression
heart failure
type diabetes
insulin resistance
bariatric surgery
obese patients
high fat diet induced
weight gain
single cell
oxidative stress
dna methylation
genome wide
left ventricular
body mass index
peripheral blood