Factors Related to Bacillus thuringiensis and Gut Physiology. Comment on Rajan, V. An Alkaline Foregut Protects Herbivores from Latex in Forage, but Increases Their Susceptibility to Bt Endotoxin. Life 2023, 13 , 2195.

A recent article has proposed that alkaline guts may lead to a general susceptibility to the biological control agent Bacillus thuringiensis and the pesticidal proteins derived from it. An analysis of the literature presented here clarifies our knowledge on the activity and safety of these agents, indicating that alkaline guts are not determinant of sensitivity and that the generalized conclusions proposed in the previous article cannot be substantiated.