Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis.

Vivek K BajpaiMd Badrul AlamKhong Trong QuanHee-Jeong ChoiHongyan AnMi-Kyoung JuSang-Han LeeYun Suk HuhYoung-Kyu HanMinKyun Na

Published in: BMC complementary and alternative medicine (2018)

Our results suggested that the compounds 4 (xanthopurpurin) and 5 (lucidin-ω-methyl ether) showed high selective toxicity towards breast cancer cells at lower concentrations without showing toxicity towards normal cells, thus could be of potential as new lead molecules in cancer treatment.

Keyphrases

breast cancer cells
induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
ionic liquid
signaling pathway
structure activity relationship
arabidopsis thaliana