Pulsed electromagnetic fields potentiate bone marrow mesenchymal stem cell chondrogenesis by regulating the Wnt/β-catenin signaling pathway.

Kangping SongJing HuMing YangYong XiaChengqi HeYonghong YangSi-Yi Zhu

Published in: Journal of translational medicine (2024)

PEMFs at 75 Hz and 3 mT are optimal in inducing early-stage chondrogenic differentiation of BMSCs. The induction and chondroprotective effects of PEMFs are mediated by sFRP3 and Wnt/β-catenin signaling, irrespective of inflammatory conditions.

Keyphrases

mesenchymal stem cells
bone marrow
early stage
umbilical cord
cell proliferation
stem cells
oxidative stress
cell therapy
squamous cell carcinoma