Systematic risk analysis of radiation pneumonitis in breast cancer: role of cotreatment with chemo-, endocrine, and targeted therapy.
Julian MangesiusDanijela MinaschKatharina FinkMeinhard Nevinny-StickelPeter LukasUte GanswindtThomas SeppiPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2022)
Common treatment schedules in sequential chemoradiation following breast-conserving surgery only moderately increase lung toxicity, mainly as an asymptomatic complication, or to a minor extent, as transient pneumonitis ≤ grade 2. However, combined treatment with tamoxifen and the LHRH analog goserelin significantly increased the risk of pneumonitis in breast cancer patients after chemoradiation. Thus, closer surveillance of involved patients is advisable.
Keyphrases
- locally advanced
- rectal cancer
- end stage renal disease
- minimally invasive
- newly diagnosed
- combination therapy
- interstitial lung disease
- chronic kidney disease
- ejection fraction
- squamous cell carcinoma
- neoadjuvant chemotherapy
- oxidative stress
- radiation therapy
- rheumatoid arthritis
- atrial fibrillation
- coronary artery disease
- subarachnoid hemorrhage