Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease.
Stefan J SchunkSarah TriemDavid SchmitStephen ZewingerTamim SarakpiEllen BeckerGregor HütterSelina WrublewskyFabienne KütingMathias HohlDalia AlansaryLeticia Prates RomaPeter LippJulia MöllmannMichael LehrkeMatthias W LaschkeMichael D MengerRafael KramannPeter BoorWilhelm Jahnen-DechentWinfried MärzMichael BöhmUlrich LaufsBarbara A NiemeyerDanilo FliserEmmanuel AmpofoThimoteus SpeerPublished in: Circulation (2021)
IL-1α represents a key mediator of leukocyte-endothelial adhesion and inflammation in AMI and CKD. Inhibition of IL-1α may serve as a novel anti-inflammatory treatment strategy.
Keyphrases
- anti inflammatory
- endothelial cells
- oxidative stress
- chronic kidney disease
- biofilm formation
- heart failure
- acute myocardial infarction
- peripheral blood
- left ventricular
- transcription factor
- cell migration
- coronary artery disease
- combination therapy
- escherichia coli
- cell adhesion
- acute coronary syndrome
- candida albicans
- percutaneous coronary intervention
- smoking cessation