Dental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort study.
Modupe O CokerPaul AkhigbeEsosa OsagieNosakhare L IdemudiaOghenero IgedegbeNneka ChukwumahRuxton AdebiyiAllison E MannLauren M O'ConnellOzo ObuekweAugustine OmoigberaleManhattan E CharuratVincent P RichardsPublished in: BMC oral health (2021)
Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated.
Keyphrases
- antiretroviral therapy
- respiratory tract
- hiv positive
- hiv infected
- gene expression
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- men who have sex with men
- oral health
- young adults
- dna methylation
- healthcare
- pregnant women
- mental health
- current status
- south africa
- health information
- atomic force microscopy
- high resolution
- combination therapy
- single molecule
- social media
- smoking cessation
- mass spectrometry