A potent and selective activator of large-conductance Ca 2+ -activated K + channels induces preservation of mitochondrial function after hypoxia and reoxygenation by handling of calcium and transmembrane potential.

Itanna Isis Araujo de SouzaThais da Silva BarencoMaria Eduarda Maciel Fernandes PavarinoMarcos Tadeu CoutoGabriel Oliveira de ResendeDahienne Ferreira de OliveiraCristiano Gonsalves PonteJosé Hamilton Matheus NascimentoLeonardo Maciel

Published in: Acta physiologica (Oxford, England) (2024)

The Compound Z acts as a mitochondrial BKCa channel activator and can protect mitochondria function against hypoxia/reoxygenation injury, by handling mitochondrial calcium and transmembrane potential.

Keyphrases

oxidative stress
nuclear factor
induced apoptosis
human health
cell death
immune response
inflammatory response