Microneedle-Mediated Delivery of siRNA Via Liposomal-Based Transfection for Inner Ear Gene Therapy.

Sharon J FengFrançois VoruzStephen LeongDaniella R HébertEugénie BreilAykut AksitMichelle YuLauren ChiribogaElizabeth S OlsonJeffrey W KysarAnil K Lalwani

Published in: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (2024)

Small volumes of siRNA and Lipofectamine can be effectively delivered to cochlear structures using microneedles, paving the way for atraumatic cochlear gene therapy.

Keyphrases

gene therapy
hearing loss
cancer therapy
high resolution
drug delivery
mass spectrometry