Systemic osteosclerosis associated with primary bone marrow B-cell lymphoma.
Shuji OzakiTsutomu IimaEtsuko SekimotoHironobu ShibataToshio ShigekiyoYukio HiguchiTakanori HirosePublished in: EJHaem (2023)
Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50-year-old man with severe systemic osteosclerosis associated with primary bone marrow B-cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.
Keyphrases
- bone marrow
- bone mineral density
- mesenchymal stem cells
- diffuse large b cell lymphoma
- drug induced
- liver failure
- soft tissue
- acute myeloid leukemia
- early onset
- nuclear factor
- intensive care unit
- postmenopausal women
- bone regeneration
- bone loss
- toll like receptor
- mechanical ventilation
- acute respiratory distress syndrome