A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer's Disease Mouse Model.

Fumito NaganumaDaiki MurataMarie InoueYuri MaehoriRyuichi HaradaShozo FurumotoYukitsuka KudoTadaho NakamuraNobuyuki Okamura

Published in: Molecular imaging and biology (2023)

A novel NIRF probe, THK-565, enabled the in vivo detection of Aβ deposits in the brains of the AD mouse model, suggesting that NIRF imaging with THK-565 could non-invasively assess disease-specific pathology in AD.

Keyphrases

mouse model
loop mediated isothermal amplification
living cells
quantum dots
label free
high resolution
real time pcr
single molecule
cognitive decline
mass spectrometry