Phytochemical analysis of Daphne pontica L. stems with their pro-apoptotic properties against DU-145 and LNCaP prostate cancer cells.

Maryam NikahdMahmoud AghaeiZulfiqar AliSeyed Ebrahim SajjadiIkhlas A KhanSeyed Mostafa Ghannadian

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2022)

varied from 0.9 - 27.3 and 25.2 - 87.4 μM, respectively. Among them, 9 exhibited selective growth inhibition against DU 145 treated cells. LNCaP cells demonstrated the highest sensitivity to treatment with compound 12.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
anti inflammatory
signaling pathway
oxidative stress
cell proliferation
pi k akt
combination therapy