MBNL-dependent impaired development within the neuromuscular system in Myotonic Dystrophy type 1.

Julie Tahraoui-BoriesAntoine MérienAnchel Gonzàlez-BarrigaJeanne LainéCéline LeteurHélène PolvècheAlexandre CarteronJuliette Duchesne De LamotteCamille NicoleauJérome PolentesMargot JarrigeMàrio Gomes-PereiraErwann VentrePauline PoydenotDenis FurlingLaurent SchaefferClaire LegayCécile Martinat

Published in: Neuropathology and applied neurobiology (2022)

Beyond the application to DM1, our approach to generating a robust and reliable human neuromuscular system should facilitate disease modelling studies and drug screening assays.

Keyphrases

endothelial cells
induced pluripotent stem cells
early onset
high throughput
case control
emergency department
metabolic syndrome
skeletal muscle
insulin resistance