Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas.

Quentin BayardStefano CarusoGabrielle CouchySandra RebouissouPaulette Bioulac SageCharles BalabaudValerie ParadisNathalie SturmAnne de MuretCatherine GuettierBenjamin BonsangChristiane CopieEric LetouzéJulien CalderaroSandrine Imbeaud Jean Charles NaultJessica Zucman-Rossi

Published in: Gut (2020)

Recurrent chromosomal alterations involving ROS1, FRK or IL6 genes lead to activation of the JAK/STAT pathway in IHCAs.

Keyphrases

cell death
dna damage
reactive oxygen species
copy number
oxidative stress
genome wide
signaling pathway
dna methylation