Ki-67 is necessary during DNA replication for fork protection and genome stability.

Konstantinos StamatiouFlorentin HuguetLukas V SerapinasChristos SpanosJuri RappsilberPaola Vagnarelli

Published in: Genome biology (2024)

We unveil a new function of Ki-67 in DNA replication and genome maintenance that is independent of its previously known role in mitosis and gene regulation.

Keyphrases

neoadjuvant chemotherapy
genome wide
gene expression
radiation therapy
locally advanced
rectal cancer