A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.

Chang LiuLibangxi LiuMinghui YangBin LiJiarong YiXuezheng AiYang ZhangBo HuangChangqing LiChencheng FengYue Zhou

Published in: Cell division (2020)

A positive feedback loop between EZH2 and NOX4 is involved in regulating NP cell senescence, which provides a novel insight into the mechanism of IDD and a potential therapeutic target for IDD.

Keyphrases

single cell
dna damage
endothelial cells
transcription factor
long non coding rna
long noncoding rna
reactive oxygen species
stress induced
oxidative stress
risk assessment
mesenchymal stem cells
climate change