JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.

Ana Isabel Giraldo-Rincón Sara Naranjo Molina Natalia Gomez-Lopera Daniel Camilo Aguirre-Acevedo Andrea Ucroz Benavidez Kenny Mauricio Galvez-Cárdenas Francisco Cuellar Ambrosí José Domingo Torres Sigifredo Ospina Ospina Katherine Palacio Lina Maria Gaviria Jaramillo Carlos Mario Muñeton Gonzalo Vasquez Palacio

Published in: Colombia medica (Cali, Colombia) (2023)

Thus, this study demonstrates the importance of the molecular characterization of the JAK2, CALR and MPL mutations in Colombian patients (the genetic context of which remains unclear in the abovementioned neoplasms) to achieve an accurate diagnosis, a good prognosis, adequate management, and patient survival.

Keyphrases

end stage renal disease
tyrosine kinase
chronic kidney disease
newly diagnosed
ejection fraction
chronic myeloid leukemia
peritoneal dialysis
gene expression
copy number