Associations between maternal plasma zinc concentrations in late pregnancy and LINE-1 and Alu methylation loci in the young adult offspring.
Amaraporn RerkasemSothida NantakoolBrooke C WilsonAmpica MangklabruksKongsak BoonyapranaiApiwat MutiranguraJosé G B DerraikKitttipan RerkasemPublished in: PloS one (2022)
Lower maternal zinc concentrations late in gestation were associated with changes in DNA methylation in later life. Thus, zinc deficiency during pregnancy may induce alterations in total LINE-1 methylation and LINE-1 hypermethylation loci. These results suggest a possible epigenetic link between zinc deficiency during pregnancy and long-term outcomes in the offspring.
Keyphrases
- dna methylation
- genome wide
- oxide nanoparticles
- pregnancy outcomes
- young adults
- gene expression
- high fat diet
- birth weight
- preterm infants
- copy number
- genome wide association study
- preterm birth
- pregnant women
- adipose tissue
- replacement therapy
- insulin resistance
- metabolic syndrome
- genome wide association
- childhood cancer