Dabigatran inhibits intravitreal thrombin activity.

Jeroen Bastiaans Verena C MulderJan C van MeursMarja Smits-Te NijenhuisConny van Holten-NeelenP Martin van HagenWillem A Dik

Published in: Acta ophthalmologica (2017)

Proliferative vitreoretinopathy (PVR) is associated with increased intravitreal thrombin activity that activates profibrotic and proinflammatory pathways in RPE cells. Our findings provide evidence that this activation pathway can potentially be inhibited by dabigatran.

Keyphrases

vascular endothelial growth factor
atrial fibrillation
induced apoptosis
diabetic retinopathy
age related macular degeneration
cell cycle arrest
endoplasmic reticulum stress
pi k akt