Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.
Anne E JusticeKristin YoungStephanie M GogartenTamar SoferMisa GraffShelly Ann M LoveYujie WangYann C KlimentidisMiguel CruzXiuqing GuoFernando HartwigLauren PettyJie YaoMatthew A AllisonJennifer E BelowThomas A BuchananYii-Der Ida ChenMark O GoodarziCraig HanisHeather M HighlandWilla A HsuehEli IppEsteban ParraWalter PalmasLeslie J RaffelJerome I RotterJingyi TanKent D TaylorAdan ValladaresAnny H XiangLisa Sánchez-JohnsenCarmen R IsasiKari E NorthPublished in: Human molecular genetics (2022)
Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.
Keyphrases
- body mass index
- weight gain
- genome wide association study
- genome wide
- insulin resistance
- genome wide association
- physical activity
- systematic review
- metabolic syndrome
- type diabetes
- total hip arthroplasty
- weight loss
- african american
- copy number
- pregnant women
- public health
- high fat diet induced
- dna methylation
- case control
- adipose tissue
- meta analyses
- risk assessment
- polycystic ovary syndrome
- risk factors
- mental health
- gene expression
- climate change
- health promotion
- health information
- middle aged
- human health
- clinical evaluation