Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention.
Alexandra Iulia IrimieCornelia BraicuSergiu PascaLorand MagdoDiana GuleiRoxana Maria CojocneanuCristina CiocanAndrei OlariuOvidiu CozaIoana Berindan-NeagoePublished in: Medicina (Kaunas, Lithuania) (2019)
Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be investigated and analyzed in terms of cancer's predisposition, development and prognosis. One of these multi-dimensional factors, which has gained increased attention in the oncological field due to its unelucidated role in risk assessment for cancer, is diet. Moreover, as studies advance, a clearer connection between diet and the molecular alteration of patients is becoming identifiable and quantifiable, thereby replacing the old general view associating specific phenotypical changes with the differential intake of nutrients. Respectively, there are two major fields concentrated on the interrelation between genome and diet: nutrigenetics and nutrigenomics. Nutrigenetics studies the effects of nutrition at the gene level, whereas nutrigenomics studies the effect of nutrients on genome and transcriptome patterns. By precisely evaluating the interaction between the genomic profile of patients and their nutrient intake, it is possible to envision a concept of personalized medicine encompassing nutrition and health care. The list of nutrients that could have an inhibitory effect on cancer development is quite extensive, with evidence in the scientific literature. The administration of these nutrients showed significant results in vitro and in vivo regarding cancer inhibition, although more studies regarding administration in effective doses in actual patients need to be done.
Keyphrases
- papillary thyroid
- end stage renal disease
- squamous cell
- risk assessment
- ejection fraction
- healthcare
- newly diagnosed
- chronic kidney disease
- physical activity
- genome wide
- heavy metals
- systematic review
- weight loss
- prognostic factors
- lymph node metastasis
- gene expression
- young adults
- prostate cancer
- childhood cancer
- weight gain
- working memory
- climate change
- single cell
- patient reported outcomes
- body mass index
- rectal cancer
- human health