Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer.
Kensho YorozuMasaki KaiboriShintarou KimuraMisa IchikawaKosuke MatsuiSoichiro KaneshigeMasanori KobayashiDaiki JimboYusuke TorikaiYoshitaka FukuzawaYoshiharu OkamotoPublished in: Journal of personalized medicine (2022)
We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. ICG liposomes were prepared by adding 5 mg of ICG to 50 mL liposomes. Later, 25 mL of ICG liposomes were diluted with 250 mL of 5% glucose solution and administered intravenously to the patient. We selected the multi-laser delivery system (MLDS), a laser irradiator for performing PDT. Further, the patients received a combination of LEM and hydrogen gas inhalation therapy throughout the treatment. We reported two cases of PDT therapy, one with middle intrathoracic esophagus carcinoma and the other with hypopharyngeal cancer. In the first case, the MLDS laser was directly attached to the endoscope and directed to the cancer area with wavelengths of 810 nm. After the treatment, a biopsy demonstrated no tumor recurrence. In the second case, the patient was treated with endovascular PDT using ICG liposomes and MLDS fiber optics. Later, tumor shrinkage was demonstrated after the first round and disappeared after six months. In conclusion, the present findings suggest that the effect of PDT using ICG liposomes with LEM and hydrogen gas may eradicate cancer without burdening patients by enhancing tumor immunity.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- drug delivery
- papillary thyroid
- drug release
- end stage renal disease
- squamous cell
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- room temperature
- case report
- type diabetes
- stem cells
- blood pressure
- metabolic syndrome
- patient reported outcomes
- blood glucose
- carbon dioxide
- combination therapy
- squamous cell carcinoma
- cell therapy
- high resolution
- patient reported
- weight loss
- visible light