Adducin family proteins possess different nuclear export potentials.
Chia-Mei LiuWen-Hsin HsuWan-Yi LinHong-Chen ChenPublished in: Journal of biomedical science (2017)
Our results suggest that ADD2 and ADD3 possess functional NLS and shuttle between the cytoplasm and nucleus. The discrepancy in the subcellular localization of the ADD isoforms arises due to their different nuclear export capabilities. In addition, the interaction of ADD1 with RNA polymerase II and zinc-finger protein 331 implicates a potential role for ADD1 in the regulation of transcription.