Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes.

Mei-Hsin Su Ying-Hsiu Shih Yen-Feng LinPei-Chun ChenChia-Yen ChenPo-Chang HsiaoJin-Town WangYu-Li LiuShih-Jen Tsai Po-Hsiu Kuo Chi-Shin Wu Yen-Tsung Huang Shih-Heng Wang

Published in: Diabetologia (2022)

The comorbidity of type 2 diabetes with psychiatric disorders may be explained by shared familial factors. The shared polygenic loading between MDD and type 2 diabetes implies not only pleiotropy but also a shared genetic aetiology for the mechanism behind the comorbidity. The negative correlation between polygenic loading for SCZ and type 2 diabetes implies the role of environmental factors.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
insulin resistance
early onset
copy number
major depressive disorder
gene expression
metabolic syndrome
skeletal muscle
adipose tissue
bipolar disorder