Neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation.

Gyuhwi LeeJong Cheon JooBo Yoon ChoiAnders M LindrothSoo Jung ParkYoon Jung Park

Published in: BMC complementary and alternative medicine (2016)

The results suggested that MPP(+)-induced cell death in the dopaminergic SH-SY5Y cells was related with transcriptional induction of HATs and increased histone H3 acetylation and that PLE might prevent the cells from MPP(+)-induced cell death via tempering histone H3 acetylation.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
diabetic rats
high glucose
pi k akt
oxidative stress
gene expression
drug induced
transcription factor
heat shock