PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN.

Xiaodan ChongJingde ChenNanxin ZhengZhuqing ZhouYanan HaiShiqing ChenYu ZhangQingzhuo YuShijun YuZhiqin ChenWenfang BaoMing QuanZhe-Sheng ChenYangyang ZhanYong Gao

Published in: Molecular cancer (2022)

Downregulation of circLHFPL2 sustains the activation of the PI3K/AKT signaling pathway via a positive feedback loop in PIK3CA-mutant CRC. In addition, downregulation of circLHFPL2 leads to MEK inhibitor resistance in CRC. Therefore, targeting circLHFPL2 could be an effective approach for the treatment of CRC patients harboring oncogenic PIK3CA mutations.

Keyphrases

signaling pathway
pi k akt
cell proliferation
end stage renal disease
ejection fraction
newly diagnosed
transcription factor
chronic kidney disease
protein kinase
induced apoptosis
epithelial mesenchymal transition
peritoneal dialysis
patient reported outcomes
drug delivery
combination therapy
patient reported