Relationship between UGT1A1*27 and UGT1A1*7 polymorphisms and irinotecan-related toxicities in patients with lung cancer.
Minoru FukudaManabu OkumuraTomomi IwakiriKazuhiko ArimoriTakuya HondaKazuma KobayashiHiroaki SenjuShinnosuke TakemotoTakaya IkedaHiroyuki YamaguchiKatsumi NakatomiNobuko MatsuoHiroshi MukaeKazuto AshizawaPublished in: Thoracic cancer (2017)
UGT1A1*27 can occur separately from UGT1A1*28 and is related to leukopenia during irinotecan treatment. UGT1A1*7 is less relevant to irinotecan-induced toxicities, and UGT1A1*29 seems to have little clinical impact.