HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer.

Yiwei HuangZhencong ChenTao LuGuoshu BiMing LiJiaqi LiangZhengyang HuYuansheng ZhengJiacheng YinJunjie XiZongwu LinCheng ZhanWei JiangQun WangLijie Tan

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our results indicated that HIF-1α functions as a critical factor in the dual role of TGF-β in tumor cells, and may be used as a biomarker or therapeutic target for TGF-β mediated cancer progression.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
papillary thyroid
type diabetes
squamous cell
blood pressure
squamous cell carcinoma
signaling pathway
adipose tissue
weight loss
hiv testing
young adults